Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma

From DNA binding to metabolic control: integration of -omics data reveals drug targets for prostate cancer.

Androgen signalling via the androgen receptor plays a critical role in prostate cancer development and is the primary drug target for prostate cancer therapy. However, given the frequent development of resistance to current therapies in many tumours, there is a great need for the identification of additional factors that could be exploited as drug targets. In this issue of The EMBO Journal, Mas...

Multi-Omics Data Integration: A Modular Approach

Substantial extent of research has been carried out over past few decades to understand the molecular and genetic level information within the cell that help improving the methodologies in the fields of agricultural or medical research. However, often the research is focused at one particular area of expertise by an individual researcher or a work group and very less number of attempts were mad...

Integrated Multiple “-omics” Data Reveal Subtypes of Hepatocellular Carcinoma

Hepatocellular carcinoma is one of the most heterogeneous cancers, as reflected by its multiple grades and difficulty to subtype. In this study, we integrated copy number variation, DNA methylation, mRNA, and miRNA data with the developed "cluster of cluster" method and classified 256 HCC samples from TCGA (The Cancer Genome Atlas) into five major subgroups (S1-S5). We observed that this classi...

A bridge between multi-omics data and the management of hepatocellular carcinoma.

Hepatocellular Carcinoma in Sheep